By Gaetano Thiene M.D., Marialuisa Valente M.D. (auth.), Cristina Basso, Marialuisa Valente, Gaetano Thiene (eds.)
Cardiac tumors have been as soon as a nosographic entity of scarce medical curiosity as a result of the rarity and of the intrinsic diagnostic and healing impossibilities, and have been thought of a deadly morbid entity. It has now develop into a topical topic because of advances in medical imaging (echo, magnetic resonance, computed tomography) in addition to innovation in applied sciences of in-vivo analysis. Cardiac Tumor Pathology provides a awesome instance of those advances with clinico-pathologic correlations. This well timed quantity covers heritage, epidemiology, demographics, scientific analysis, pathology, imaging via echo, CT and MRI of either benign and malignant cardiac tumors, both basic or secondary. Chemotherapy of malignant neoplasms can also be addressed. certain emphasis is given to clinico-pathologic correlations. With all chapters written by means of specialists of their fields, this quantity will function an invaluable source for physicians facing, and attracted to, this distinct department of cardiac oncology and may symbolize an invaluable advisor for pathologists, clinicians, cardiologists, cardiac surgeons, and radiologists in addition to for postgraduate scholars education in those areas.
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Teratoma. Four patients, one male and three female, age ranging 1 month–35 years (median 1 month) were operated, all but one presenting with congestive heart failure since birth and with radiographic and echocardiographic evidence of pericardial mass. Rhabdomyoma. Six patients, three female and three male, age ranging 7 days–4 months (mean 46 ± 47 days, median 22 days), had a surgically resected rhabdomyoma. In all, cardiac rhabdomyoma had an intracavitary growth with obstructive symptoms, at the level of the left ventricular outflow tract in four and of the right ventricular outflow tract in two.
Pucci Fig. Reprinted with permission of the Italian Society of Cardiology. (a) Glands are present at the base of a myxoma. (b) High power view of glandular epithelium. Immunoreactivity of glandular epithelium for (c) pan-cytokeratin (AE1/AE3), (d) carcynoembryonic antigen (CEA), (e) protein S100, (f) neuron-specific enolase (NSE), cytokeratins 7 (g) and 20 (h) or (i) chromogranin A. Hematoxylin and eosin (a, b) avidin–biotin complex, hematoxylin counterstaining (c–i) dystrophic calcifications (with possible GhandiGamna sclerosiderotic areas and granulation tissue) and/or metaplastic ossification together with limited foci of necrosis .
As other benign tumors of soft tissues, cardiac myxomas do not show a correspondent malignant counterpart, and myxosarcoma is not a recognized entity in the present classifications of soft tissue tumors . In the past, cases of myxosarcoma have been reported but today they could rather be classified as myxoid rhabdomyosarcoma, leiomyosarcoma, fibrosarcoma, low-grade 41 fibromyxoid sarcoma, etc. 1) [1, 18, 20, 70, 77, 78]. Then, a relapsing myxoid cardiac tumor has to be differentiated from a myxoid sarcoma after excluding incomplete resection of a myxoma or a multicentric myxoma in the case of Carney complex.
Cardiac Tumor Pathology by Gaetano Thiene M.D., Marialuisa Valente M.D. (auth.), Cristina Basso, Marialuisa Valente, Gaetano Thiene (eds.)