Get Cancer Symptom Science : Measurement, Mechanisms, and PDF

By Charles S. Cleeland, Michael J. Fisch, Adrian J. Dunn

ISBN-10: 0511780869

ISBN-13: 9780511780868

ISBN-10: 0521869013

ISBN-13: 9780521869010

Melanoma Symptom technology is the 1st interdisciplinary compilation of analysis at the mechanisms underlying the expression of cancer-related signs. It provides techniques in scientific, animal and in vitro study, study equipment in mind imaging, and statistical-descriptive methods to realizing the mechanistic foundation of symptom expression. This quantity additionally presents views from sufferers, executive and undefined. by means of amassing and synthesizing the constructing threads of recent methods to knowing cancer-related signs, the ebook promotes a pioneering framework for merging behavioral and organic disciplines to explain mechanisms of symptom evolution, incorporating new applied sciences, trying out novel brokers for symptom regulate, and bettering sufferer functioning and caliber of lifestyles either in the course of and after melanoma remedy. With knowledgeable editorial group led through Charles S. Cleeland, an internationally-recognized chief in melanoma ache evaluation and remedy, this is often crucial examining for surgical, medical and scientific oncologists, educational researchers, and pharmaceutical businesses constructing new brokers to manage symptom expression
Preface; Foreword; half I. creation: 1. creation to melanoma Symptom technological know-how Charles S. Cleeland, Adrian J. Dunn and Michael J. Fisch; 2. learning the mechanisms underlying the indications of sufferers with melanoma Adrian J. Dunn; three. Cytokines, disorder habit: a version for melanoma signs Steven S. Zalcman, Randall T. Woodruff, Ruchika Mohla and Allan Siegal; half II. melanoma Symptom Mechanisms and versions: scientific and easy technology: four. The medical technological know-how of melanoma discomfort evaluation and administration Russell okay. Portenoy and Victor T. Chang; five. ache: easy technology: 5a. Mechanisms of disease-related discomfort in melanoma: insights from the research of bone tumors Patrick W. Mantyh and Juan Miguel Jimenez Andrade; 5b. Neuropathic ache: uncomplicated technological know-how Patrick M. Dougherty and Haijun Zhang; 6. Cognitive disorder: is chemobrain genuine? Christina A. Meyers and Jeffrey S. Wefel; 7. Cognitive impairment: uncomplicated technology Perry N. Fuchs, Jessica A. Boyette-Davis and Adrian J. Dunn; eight. melancholy in melanoma: pathophysiology on the mind-body interface Andrew H. Miller, Michael A. Burke and Charles L. Raison; nine. Depressive sickness: uncomplicated technological know-how: 9a. Animal types of depressed temper and illness habit Adrian J. Dunn; 9b. From irritation to illness and melancholy: the cytokine connection Robert Dantzer and Keith W. Kelly; 10. Cancer-related fatigue: scientific technology Xin Shelley Wang; eleven. constructing translational animal versions of cancer-related fatigue Mary W. Meagher; 12. melanoma anorexia/weight loss syndrome Aminah Jatoi and Nisha Lassi; thirteen. urge for food loss/cachexia: uncomplicated technology Tristin D. Brisbois-Clarkson, Wendy V. Wismer and Vickie E. Baracos; 14. Sleep and its issues: scientific technological know-how Sofia Ancoli-Israel and Lianqi Liu; 15. Sleep and its issues Mark R. Opp and Luca Imeri; sixteen. Proteins and indicators Bang-Ning Lee and James M. Reuben; 17. Genetic methods to treating and combating signs in sufferers with melanoma Quiling Shi and Charles S. Cleeland; 18. useful imaging of signs T. Dorina Papageorgiou, Edward F. Jackson and Javier O. Valenzuela; 19. High-dose remedy and posttransplantation symptom burden: notable a stability Sergio A. Giralt and Loretta A. Williams; half III. medical views in Symptom administration and examine: 20. selling symptom examine in cooperative teams Lynne I. Wagner and David Cella; 21. useful points of symptom administration in sufferers with melanoma Richard T. Lee and Michael J. Fisch; half IV. Symptom size: 22. Symptom dimension through sufferer document Charles S. Cleeland and Tito R. Mendoza; 23. The economics of cancer-related signs: valuing supportive care interventions Lesley-Ann Miller and Jane C. Weeks; 24. Longitudinal types for signs Diane L. Fairclough; 25. Bayesian adaptive layout: a brand new method of try out the effectiveness of symptom-reducing brokers utilizing patient-reported results Valen E. Johnson and Tito R. Mendoza; half V. executive and views: 26. selling melanoma symptom technological know-how examine Ann O'Mara and Maria Sgambati; 27. constructing symptom administration medicinal drugs Joanna M. Brell and Lori M. Minasian; 28. Cancer-related signs: matters for attention in drug and healing organic product label claims within the usa Jane A. Scott; 29. Symptom examine: having a look forward Charles S. Cleeland, Adrian J. Dunn and Michael J. Fisch; Index

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3. Categories of adjuvant analgesics Purpose Analgesic Multiple purposes Corticosteroids Antidepressants Alpha-2 adrenergic agents Topical drugs Neuropathic pain Anticonvulsants NMDA receptor antagonists Sodium channel blockers GABA agonists Cannabinoids Bone pain Bisphosphonates Calcitonin Pain related to bowel obstruction Anticholinergic drugs Somatostatin analogues NMDA indicates N-methyl-d-aspartate; GABA, gammaaminobutyric acid. gov. the older tricyclic antidepressants and the newer dual reuptake inhibitors such as duloxetine and milnacipran have strong evidence of analgesic efficacy.

Human immunodeficiency virus type 1 tropism for brain microglial cells is determined by a region of the env glycoprotein that also controls macrophage tropism. J Virol 66(4):2588–2593, 1992. 35. Barak O, Weidenfeld J, Goshen I, Ben-Hur T, Taylor AN, Yirmiya R. Intracerebral HIV-1 glycoprotein 120 produces sickness behavior and pituitary-adrenal activation in rats: role of prostaglandins. Brain Behav Immun 16(6):720–735, 2002. 36. Barak O, Goshen I, Ben-Hur T, Weidenfeld J, Taylor AN, Yirmiya R.

Interventional techniques. Interventional approaches include injections, nerve blocks, and implanted devices that may deliver medication or provide neurostimulation. While only 5% to 10% of patients are estimated to require interventional measures for pain control, patients with severe pain are more likely to be seen by palliative care teams or pain specialists and to be evaluated as candidates for these kinds of interventions. Patient selection and the timing of these interventions in the disease course (sooner or later) are important clinical variables.

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Cancer Symptom Science : Measurement, Mechanisms, and Management by Charles S. Cleeland, Michael J. Fisch, Adrian J. Dunn


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