Get Cancer precursors: epidemiology, detection, and prevention PDF

By Eduardo L. Franco, Thomas E. Rohan, J.F. Fraumeni

ISBN-10: 0387951881

ISBN-13: 9780387951881

Drs. Franco and Rohan compile a well timed and accomplished set of experiences describing the biologic foundation of carcinogenesis, concerns on the topic of size and interpretation of melanoma precursors, website particular precancerous stipulations, and keep an eye on of melanoma precursors ...The ebook has a number of vital strengths, such a lot particularly the wealth of present info on melanoma precursors and similar issues supplied through a powerful solid of melanoma researchers. ... it successfully offers particular and compelling purposes for learning melanoma precursors, the main updated and entire choice of studies at the subject, and a pragmatic photo of the complexities dealing with examine of melanoma precursors. -American magazine of Epidemiology

''In this e-book, Drs. Franco and Rohan have succeeded in getting ready a finished, well timed, and important assessment of the huge development that has been made in our knowing of melanoma precursors. they've got enlisted specialists within the box who've contributed authoritative chapters to a large choice of cancers with emphasis at the etiology and ordinary background, together with the function of environmental and heritable issue that impress general cells to endure malignant transformation. Epidemiologic info are associated each time attainable to molecular in addition to clasical mobile pathology, supplying a fuller realizing of the informal occasions and mechanisms that begin the carcinogenic process.'' -From the Foreward via Joseph F. Fraumeni, Jr., M.D., M.S. Director, department of melanoma Epidemiology and Genetics nationwide melanoma Institute nationwide Institutes of future health Rockville, MD

This e-book offers an summary of the growth made within the previous few years at the epidemiology, detection equipment, and preventive stategies for melanoma precursors. individuals to the 25 chapters are one of the world's such a lot a professional scientists within the parts of molecular pathology, epidemiology, and regulate of melanoma precursors. Their reports of the subject are available to a wide expert base that comes with uncomplicated melanoma researchers, medical oncologists, pathologists, molecular biologists, epidemiologists, nurses, wellbeing and fitness pros engaged on coverage implications, and graduate scholars in cancer-related fields.

Divided into 5 sections, the ebook starts off with short overviews of the molecular foundation of carcinogenesis and of the histological features of melanoma precursors. concerns concerning the size, interpretation, and the research of precursor lesions are addressed partially II, together with well timed chapters on epidemiologic methods to learning intermediate endpoints, the influence of size errors, and strategies of processing organic specimens for molecular epidemiology reviews. the most element of the textual content is located partially III, with chapters on melanoma precursors on the most vital anatomical websites at which good tumors take place, together with the lung, breast, colon, esophagus, and prostate. The site-specific reports contain discussions of the epidemiology of these lesions, and, the place applicable, elements in their detection and prevention. the ultimate sections of the publication characteristic precious overviews on screening and prevention concepts and the function of evidence-based drugs in judging the price of such thoughts for nationwide and overseas coverage directions on melanoma regulate.

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59. Ross RK, Yuan JM, Yu MC, et al. Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma. Lancet 1992; 339:943–6. 60. Qian GS, Ross RK, Yu MC, et al. A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People’s Republic of China. Cancer Epidemiol Biomarkers Prev 1994; 3:3–10. 61. Chen CJ, Yu MW, Liaw YF, et al. M. Santella 62. 63. 64. 65. 66. 67. 68. 69. 70. 71. 72. 73. 74. 75. hepatocellular carcinoma. Am J Hum Genet 1996; 59:128–34. Chen CJ, Wang LY, Lu SN, et al.

Cutaneous, ocular, and neurologic abnormalities in 830 published cases. Arch Dermatol 1987; 123:241–50. 16. Lutz WK. Quantitative evaluation of DNA binding data for risk estimation and for classifi- 1. Mechanisms and Biological Markers of Carcinogenesis 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. cation of direct and indirect carcinogens. J Cancer Res Clin Oncol 1986; 112:85–91. Poirier MC, Beland FA. DNA adduct measurements and tumor incidence during chronic carcinogen exposure in animal models: Implications for DNA adduct-based human cancer risk assesment.

Xeroderma pigmentosum. Cutaneous, ocular, and neurologic abnormalities in 830 published cases. Arch Dermatol 1987; 123:241–50. 16. Lutz WK. Quantitative evaluation of DNA binding data for risk estimation and for classifi- 1. Mechanisms and Biological Markers of Carcinogenesis 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. cation of direct and indirect carcinogens. J Cancer Res Clin Oncol 1986; 112:85–91. Poirier MC, Beland FA. DNA adduct measurements and tumor incidence during chronic carcinogen exposure in animal models: Implications for DNA adduct-based human cancer risk assesment.

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Cancer precursors: epidemiology, detection, and prevention by Eduardo L. Franco, Thomas E. Rohan, J.F. Fraumeni


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