Download e-book for iPad: Calcium signalling: Approaches and Findings in the Heart and by Lars Kaestner

By Lars Kaestner

ISBN-10: 3642346162

ISBN-13: 9783642346163

ISBN-10: 3642346170

ISBN-13: 9783642346170

The e-book combines normal strategies and techniques to enquire calcium signalling in cells starting from molecular biology methods to manipulation of calcium in dwelling cells. the point of interest inside of those equipment in at the large diversity of fluorescence imaging expertise, particularly on optical sectioning thoughts and speedy picture acquisition. as well as those basic guidance there are program examples in a context past calcium signalling in significant fields: investigations of remoted cardiac myocytes and purple blood telephone comparable study. whereas the mobile cardiology part offers snapshots of definite calcium signalling elements, the pink blood phone half provides an summary from the useful identity of calcium-channels to an idea of physiological and pathophysiological relevance.

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Extra resources for Calcium signalling: Approaches and Findings in the Heart and Blood

Sample text

2 Cardiac contraction Contraction is the functional parameter of the heart that is mediated by calcium; however, the actual readout can be diverse. The readout can be based on measurements of the entire organ in vivo by means of sonography or magnet resonance imaging, which is depicted in ⊡ Fig. 1. Alternatively, it can be measured on isolated hearts by a Millar tip catheter70. As imaging is based on geometric changes and other functional parameters, such as ejection fraction or fractional shortening, the Millar tip catheter is a pressure measurement with direct correlation to a force.

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Calcium signalling: Approaches and Findings in the Heart and Blood by Lars Kaestner

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