Read e-book online Calcium Signalling and Disease: Molecular Pathology of PDF

By M.J. HAYES, R.E. LONGBOTTOM, M.A. EVANS, S.E. MOSS (auth.), Ernesto Carafoli, Marisa Brini (eds.)

ISBN-10: 1402061900

ISBN-13: 9781402061905

ISBN-10: 1402061919

ISBN-13: 9781402061912

This subject is a brand new access within the quarter of mobile calcium signaling: but, it now spans the whole zone, with discoveries that conceal either genetic and bought pathologies, even providing glimpses towards treatment.

Cellular calcium homeostasis, and hence calcium signalling, is principally regulated by means of membrane intrinsic proteins and calcium sensor proteins. either sessions should be fascinated by pathological procedures that have an effect on either human and animals, starting from universal and significant illnesses (e.g. migraine, diabetes, epilepsia, manic melancholy, infertility, quite a few varieties of melanoma, Alzheimer’s disorder, muscular dystrophy) to infrequent genetic stipulations (e.g., a couple of genetic middle stipulations, autoimmune retinopathies, evening blindness, hereditary amyloid polyneuropathy, malignant hyperthermia, cerebellar ataxia, atherothrombotic disease).

Clearly, the subject has now develop into not just very huge, but additionally very stimulating. Its vast severe assurance is probably going to ultimately stimulate fruitful interdisciplinary discussions.

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J. Tilders, 1998, Effect of annexin-1 on experimental autoimmune encephalomyelitis (EAE) in the rat. Clin Exp Immunol. 111(1):198–204. L. Prognostic significance of annexin VII expression in glioblastomas multiforme in humans. J Neurosurg. 2003 Nov; 99(5): 886–92. S. and T. Hunter, 1986, Modulation of p36 phosphorylation in human cells: studies using anti-p36 monoclonal antibodies. Mol. Cell Biol. 6, 2745–2751. H. Numano, 2001, Potential role of recombinant annexin II in diabetic vascular injury.

Na, 2002, Inhibition of cytosolic phospholipase A2 by annexin I. Specific interaction model and mapping of the interaction site. J Biol Chem. 276(19):15712–9. , and E. Gulbins, 2005, Annexin II is a novel receptor for Pseudomonas aeruginosa. Biochem Biophys Res Commun. 327(3):900–6. C. Lieske, 2003, Annexin II is present on renal epithelial cells and binds calcium oxalate monohydrate crystals. J Am Soc Nephrol. 14(2): 289–97. , Sri, and J. Widada, 2001, Implication of annexin 1 in phagocytosis: effects of n-terminal domain deletions and point mutations of the phosphorylation site Ser-27.

2000). , 2001). Abundant and disorganized mitochondria have also been observed. 14. MOLECULAR MECHANISMS The molecular mechanism of the disease has not been established, but a number of suggestions arising from experimental findings have been put forward. NfkB/apoptosis NF- Bs are dimeric transcription factors that play a central role in the regulation of diverse biological processes, including cell growth and survival. In resting cells, NF- B dimers are sequestered in the cytoplasm as latent complexes through binding inhibitors containing ankyrin repeat domains (ARD), called I B (inhibitor of B) proteins.

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Calcium Signalling and Disease: Molecular Pathology of Calcium by M.J. HAYES, R.E. LONGBOTTOM, M.A. EVANS, S.E. MOSS (auth.), Ernesto Carafoli, Marisa Brini (eds.)


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