Breast Pathology: A Volume in the Series: Foundations in by Frances P. Malley, Sarah E. Pinder, Anna Marie Mulliga PDF

By Frances P. Malley, Sarah E. Pinder, Anna Marie Mulliga

ISBN-10: 1437717578

ISBN-13: 9781437717570

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Extra resources for Breast Pathology: A Volume in the Series: Foundations in Diagnostic Pathology

Example text

They are, nevertheless, very helpful for assessment of tumor size and distance to margins in wide local excision specimens and, if resources permit, can be very valuable. The margins of a therapeutic wide local excision specimen should be thoroughly examined. As an 15 CHAPTER 2 Handling of Surgical Specimens absolute minimum, the nearest margin to the abnormality must be sampled. However, in a recent study, when disease was thought to be 5 to 9 mm from the margin, macroscopically 21% of cases had disease within 5 mm of the edge.

Nipple Discharge subsequent excisional biopsy is indicated to exclude the diagnosis of possible papillary carcinoma/DCIS, as such lesions can be heterogeneous. Rarely, multiple papillomas present more peripherally, invariably in a segmental distribution. This can present a management problem as follow-up is difficult and the risk of associated DCIS is significant. Surgery with segmental excision and oncoplastic partial breast reconstruction may be the best option in such cases. Autoimmune Mastitis Granulomatous mastitis is an uncommon condition, usually presenting in the third or fourth decade.

It is, however, also the case that surgeons 12 will undertake excisions in differing ways and each laboratory/pathologist requires knowledge of the operation performed for each patient, including the surgical method used and the anatomic boundaries of the resection (see later). Both diagnostic and therapeutic surgical excisions may contain a nonpalpable lesion, and resection may require image-guided localization using wire, dye, or radioisotope. Whichever surgical technique is used, an understanding of this allows the pathologist to handle the specimen in such a way as to provide a high-quality diagnosis and, in particular for cancer cases, the histologic minimum data set for breast carcinomas.

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Breast Pathology: A Volume in the Series: Foundations in Diagnostic Pathology by Frances P. Malley, Sarah E. Pinder, Anna Marie Mulliga


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