New PDF release: Brain Tumors: Biology, Pathology and Clinical References

By Professor Dr. Davide Schiffer, Professor Dr. Maria Teresa Giordana, Dr. Alessandro Mauro, Dr. Riccardo Soffietti (auth.)

ISBN-10: 3540558640

ISBN-13: 9783540558644

ISBN-10: 3540616225

ISBN-13: 9783540616221

ISBN-10: 364260529X

ISBN-13: 9783642605291

ISBN-10: 3642644457

ISBN-13: 9783642644450

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Extra resources for Brain Tumors: Biology, Pathology and Clinical References

Sample text

These changes, represented by translocations onto 17p or chromosome 17 loss, were different from abnormalities usually detected in astrocytomas and medulloblastomas. Chromosomal abnormalities found in medulloblastomas are different from those described in malignant gliomas. Structural changes, such as isochromosome 17q (resulting in loss of one copy of 17p), translocations (8;11), unbalanced translocations of 20q 13, and deletions of 6q, 11, and 16q are more common than gain or losses of whole chromosomes [250, 1169,422].

Taking into account the fact that overexpression of MDM2 gene in astrocytomas is rare [2962, 2420, 2755, 2887, 2736], nuclear accumulation of wildtype p53 is probably a physiological response to DNA damage that accumulates in higher-grade tumors. In association with overexpression of wild-type p53, astrocytic gliomas express bcl-2, which is known to inhibit apoptosis mediated by p53 [32]. Over expression of p53, revealed by immunohistochemistry, has been proposed as an indicator of poor prognosis in PNET patients [1513].

In oligodendrogliomas, LOH for 19q is frequently closely associated with allelic deletions of the short arm of chromosome 1 [2756, 1776]. LOH for chromosome Ip has been described in 67% of oligodendrogliomas and in 19% of mixed gliomas [2756]. These results suggest that a putative tumor suppressor gene, located on chromosome 1p, is involved in oligodendroglioma tumorigenesis in conjunction with the one suspected on 19p. In agreement with findings in malignant astrocytic tumors, anaplastic oligodendrogliomas and oligo astrocytomas frequently show LOH on 9p and 10 and epidermal growth factor receptor (EGFR) gene amplification [2756], suggesting common pathways leading to malignancy.

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Brain Tumors: Biology, Pathology and Clinical References by Professor Dr. Davide Schiffer, Professor Dr. Maria Teresa Giordana, Dr. Alessandro Mauro, Dr. Riccardo Soffietti (auth.)


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