By Professor Dr. Davide Schiffer, Professor Dr. Maria Teresa Giordana, Dr. Alessandro Mauro, Dr. Riccardo Soffietti (auth.)
Read Online or Download Brain Tumors: Biology, Pathology and Clinical References PDF
Best pathology books
Ectoparasites are of growing to be value in glossy veterinary medication and a close realizing of the biology of those parasites is key to their applicable remedy and keep an eye on. The authors of this e-book have consequently supplied an entire evaluate of the biology, and behavior of arthropod ectoparasites in addition to the pathology and therapy of illnesses in farm animals and better half animals of temperate habitats.
Cardiac tumors have been as soon as a nosographic entity of scarce scientific curiosity as a result of the rarity and of the intrinsic diagnostic and healing impossibilities, and have been thought of a deadly morbid entity. It has now develop into a topical topic as a result of advances in scientific imaging (echo, magnetic resonance, computed tomography) in addition to innovation in applied sciences of in-vivo prognosis.
There were many advances within the box of gastrointestinal pa thology that are of substantial medical importance through the thirteen years because the final booklet of a quantity of present subject matters in Pathology dedicated to this topic. Many have arisen from the app lication of latest innovations of histochemistry, immunocytochemi stry, quantitative morphometry and molecular and mobilephone biology to gastrointestinal ailments, yet a few, significantly the popularity of the organization of Campylobaeter pylori with the most typical form of power gastritis, were completed utilizing such lengthy validated 'routine' histological approaches that one wonders how their signifi cance had escaped reputation for thus lengthy.
This new text―a collaborative attempt among scholars and academics on the collage of Wisconsin institution of Medicine―provides a distinct introductory evaluate of renal sickness, together with high blood pressure and renal transplantation, themes no longer constantly coated in different texts. It totally discusses the pathophysiology of renal problems, utilizing case histories and modern info that will help you delight in the mechanisms of those ailments and achieve a greater figuring out of the therapies to be had.
- Robbins & Cotran Pathologic Basis of Disease, 9e
- Histology and Cell Biology
- Atlas of Liver Pathology
- Scrotal Pathology
Extra resources for Brain Tumors: Biology, Pathology and Clinical References
These changes, represented by translocations onto 17p or chromosome 17 loss, were different from abnormalities usually detected in astrocytomas and medulloblastomas. Chromosomal abnormalities found in medulloblastomas are different from those described in malignant gliomas. Structural changes, such as isochromosome 17q (resulting in loss of one copy of 17p), translocations (8;11), unbalanced translocations of 20q 13, and deletions of 6q, 11, and 16q are more common than gain or losses of whole chromosomes [250, 1169,422].
Taking into account the fact that overexpression of MDM2 gene in astrocytomas is rare [2962, 2420, 2755, 2887, 2736], nuclear accumulation of wildtype p53 is probably a physiological response to DNA damage that accumulates in higher-grade tumors. In association with overexpression of wild-type p53, astrocytic gliomas express bcl-2, which is known to inhibit apoptosis mediated by p53 . Over expression of p53, revealed by immunohistochemistry, has been proposed as an indicator of poor prognosis in PNET patients .
In oligodendrogliomas, LOH for 19q is frequently closely associated with allelic deletions of the short arm of chromosome 1 [2756, 1776]. LOH for chromosome Ip has been described in 67% of oligodendrogliomas and in 19% of mixed gliomas . These results suggest that a putative tumor suppressor gene, located on chromosome 1p, is involved in oligodendroglioma tumorigenesis in conjunction with the one suspected on 19p. In agreement with findings in malignant astrocytic tumors, anaplastic oligodendrogliomas and oligo astrocytomas frequently show LOH on 9p and 10 and epidermal growth factor receptor (EGFR) gene amplification , suggesting common pathways leading to malignancy.
Brain Tumors: Biology, Pathology and Clinical References by Professor Dr. Davide Schiffer, Professor Dr. Maria Teresa Giordana, Dr. Alessandro Mauro, Dr. Riccardo Soffietti (auth.)