By James R. Berenson
Specialist physicians and scientific researchers summarize and clarify all of the fresh advances within the biology and remedy of bone marrow-based malignancy. at the organic facet, the authors convey the features of the malignant telephone and describe the numerous roles performed by way of oncogenic alterations, chromosomal anomalies, Kaposi's sarcoma herpes virus, and cytokines. New epidemiological findings and prognostic components also are analyzed. at the medical part, the authors offer a complete evaluate of traditional remedy regimens, in addition to a dialogue of more recent experimental methods regarding immunologic focusing on, inhibitors of drug resistance, and antitumor brokers.
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Additional info for Biology and Management of Multiple Myeloma (Current Clinical Oncology)
Friedman GD. Multiple myeloma: relation to propoxyphene and other drugs, radiation and occupation. Int J Epidemiol 1986; 15:423–425. 41. Pottern LM, Heineman EF, Olsen JH, Raffn E, Blair A. Multiple myeloma among Danish women: employment history and workplace exposure. Cancer Causes Control 1992; 3:427–432. 42. Heineman EF, Olsen JH, Pottern LM, Gomez M, Raffn E, Blair A. Occupational risk factors for multiple myeloma among Danish men. Cancer Causes Control 1992; 3:555–568. Chapter 2 / Epidemiology of MM and Related Disease 33 43.
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Furthermore, the immunoglobulin gene locus appears responsible for a significant proportion of the translocations that occur within the myeloma cell. The characterization of these translocations has led to the identification of a number of potential oncogenes that may play a major role in the disease development. Thus, a clear understanding of normal immunoglobulin gene rearrangement is needed to understand myeloma pathophysiology. 2. NORMAL IMMUNOGLOBULIN GENE REARRANGEMENT Antibodies are proteins that bind to cellular, bacterial, or viral antigens and, thus, signal their need for removal by the immune system.
Biology and Management of Multiple Myeloma (Current Clinical Oncology) by James R. Berenson