By Ann M. Dvorak
Basophils and mast cells are comparable yet exact secretory cells with a well-documented function in immediate-hypersensitivity reactions. The presence of those cells in numerous telephone mediated allergy reactions, in tissues of a number of illnesses, and as an element of the host response to harm and service in several situations is celebrated. liberate of saved and newly generated mediators of irritation from basophils and mast cells contributes to the cascade of pathogenetic occasions in conditions lower than which those unlock reactions ensue. regardless of insights received via reviews of those pathologic occasions, the function of basophils and mast cells and their secretory items in overall healthiness isn't recognized. during this booklet, I evaluation a lot of the structural information about basophils and mast cells of a number of species. Ultrastructural reviews of rat mast cells traditionally precede and quantitatively exceed related reviews of basophils and mast cells of alternative species. for that reason, I first evaluate those history reviews as an entity. Then I talk about the contents of 2 well-known organelles-granules and lipid bodies-in basophils and mast cells of a number of species. The ultrastructural morphology of basophils and mast cells in 3 species is gifted intimately to set up applicable guidance for his or her attractiveness and to supply basic principles for research that are acceptable for the id of those cells in different species as well.
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Additional info for Basophil and Mast Cell Degranulation and Recovery
48 Chapter 3 FIGURE 25. Autoradiograph of isolated human lung mast cells showing incorporation of radio labeled sulfur in granules. lm. (A. M. Dvorak and L. M. ) Ultrastructural autoradiographic studies have localized radiolabeled sulfur to granules in human (Figure 25) and mouse (Figure 26) mast cells (A. M . , 1982; A. M. Dvorak and L. M. Lichtenstein, unpublished data). , 1988). , 1982). , 1983c). More recently, heparin has been shown to be present in mature mouse mast cells whose granule chambers are nearly Contents of Granules and Lipid Bodies 49 FIGURE 26.
Dvorak , I. Hammel , and S. J. ) 48 Chapter 3 FIGURE 25. Autoradiograph of isolated human lung mast cells showing incorporation of radio labeled sulfur in granules. lm. (A. M. Dvorak and L. M. ) Ultrastructural autoradiographic studies have localized radiolabeled sulfur to granules in human (Figure 25) and mouse (Figure 26) mast cells (A. M . , 1982; A. M. Dvorak and L. M. Lichtenstein, unpublished data). , 1988). , 1982). , 1983c). More recently, heparin has been shown to be present in mature mouse mast cells whose granule chambers are nearly Contents of Granules and Lipid Bodies 49 FIGURE 26.
I •\. 0 0. , .... .. ·' ..... .. .. :. ·. •o 0 • .. ' : .. •' I ,• •. • : 0 ·. •o• . • • I' ' '' . '••..... · •. ·•... ..... \ ... ,. • :a ... ... ... •' ' '' FIGURE 27. Rat peritoneal mast cell, fixed for 7 s by a microwave-assisted aldehyde fixation method and then prepared for the immunogold localization of chymase. Numerous gold particles are present over the granules. Cytoplasm and mitochondria (M) are not labeled. m. From Login eta/. (1987) with permission.
Basophil and Mast Cell Degranulation and Recovery by Ann M. Dvorak