By Irma Pereira MT (ASCP) SH, Tracy I. George MD, Daniel A. Arber MD
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Extra info for Atlas of Peripheral Blood: The Primary Diagnostic Tool
A few red cells demonstrate fine basophilic stippling, which is also likely a consequence of abnormal red cell maturation. coarse basophilic stippling, nucleated red cells, and Pappenheimer bodies can be seen. 2). 2 BLOOD FINDINGS IN MYELODYSPLASIA Microcytic anemia Normocytic anemia Macrocytic anemia Dimorphic red blood cells Oval macrocytes Dacrocytes Pappenheimer bodies Nucleated red blood cells Coarse basophilic stippling may exhibit giant, hypogranular forms. Circulating blasts can also be appreciated, a finding which is a harbinger of worse disease.
12. 9 Thalassemia intermedia. Thalassemia intermedia shows a microcytic anemia with increased numbers of polychromatophilic red cells and coarse basophilic stippling. Frequent dacrocytes are present. 10 Thalassemia major. Peripheral blood smear from a patient with beta thalassemia major and multiple red cell transfusions. Two populations of RBCs are present. The first is a population of severely hypochromic microcytic red cells, some being target cells and others containing inclusions (arrow). Many of these RBCs show ragged red cell membranes.
1 MACROCYTOSIS Oval Round Megaloblastic anemia Myelodysplasia Congenital dyserythropoietic anemia, types I, III, IV Reticulocytosis Liver disease Alcoholism and alcoholic liver disease 36 The myelodysplastic syndromes are clonal, premalignant disorders of hematopoiesis resulting in abnormal morphology and maturation. They can involve one or more cell lines and, in addition to affecting white cells and platelets, can manifest dyserythropoietic changes in the bone marrow and peripheral blood. The peripheral blood findings are most evident as an anemia with oval macrocytes and dacrocytes (Fig.
Atlas of Peripheral Blood: The Primary Diagnostic Tool by Irma Pereira MT (ASCP) SH, Tracy I. George MD, Daniel A. Arber MD