By Iwao Ojima, Gregory D. Vite, Karl-Heinz Altmann
Describes leading edge methods within the improvement of anticancer brokers for chemotherapy. those new and interdisciplinary techniques are geared toward the improvement of tumor particular anticancer brokers whereas expanding the efficiency opposed to drug-resistant tumors. the amount contains an summary of latest paradigms for melanoma drug discovery and improvement via NCI, new new release cytotoxic brokers, mechanism dependent enzyme inhibitors as anticancer brokers, anti-angiogenesis brokers, antitumor vaccines, and tumor activated prodrugs utilizing immunoconjugates of monoclonal antibodies with cytotoxic brokers.
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Additional info for Anticancer Agents: Frontiers in Cancer Chemotherapy
Zangwill KM, Hamilton DH, Perkins BA, et al. Cat scratch disease in Connecticut. Epidemiology, risk factors, and evaluation of a new diagnostic test. N Engl J Med. 1993;329:8–13. 4. Klotz SA, Ianas V, Elliott SP. Cat-scratch disease. Am Fam Physician. 2011;83:152–5. 5. Miller-Catchpole R, Variakojis D, Vardiman JW, et al. Cat scratch disease. Identification of bacteria in seven cases of lymphadenitis. Am J Surg Pathol. 1986;10:276–81. 6. Bergmans AM, Rossen JW. Detection of Bartonella spp. DNA in clinical specimens using an internally controlled real-time PCR assay.
Am J Surg Pathol. 1989;13:909–20. Gasquet S, Maurin M, Brouqui P, et al. Bacillary angiomatosis in immunocompromised patients. AIDS. 1998;12:1793–803. Lymphogranuloma Venereum Lymphadenitis Lymphogranuloma venereum (LGV) is a type of lymphadenitis cause by Chlamydia trachomatis, a sexually transmitted obligatory intracellular bacterium. The bacterium consists of 15 pathogenic serovariants (serovars) that are the causative agent of ocular trachoma (serovars A–C), genital tract infection (serovars D–K) and LGV (serovars L1–L3) [1, 2].
1 summarizes some of the many causes of chronic granulomatous lymphadenitis. Whereas the etiology of chronic granulomatous inflammation may be identified or inferred in a subset of cases on the basis of histologic, microbiologic, serologic, and/or clinical findings, many may be relegated to the category of chronic granulomatous lymphadenitis, not otherwise specified, in the absence of a specific etiologic agent [2, 3]. ) Crohn disease Foreign body (eg, suture, wood) Berylliosis Various minerals Wegener granulomatosis Churg–Strauss syndrome Rheumatoid/rheumatic disease Infectious granulomatous lymphadenitis Usually suppurative Tularemia Cat-scratch disease Yersinia lymphadenitis Lymphogranuloma venereum Brucellosis Fungal infectionsa Usually nonsuppurative Tuberculosis Nontuberculous mycobacterial infection Leprosy Toxoplasmosis Leishmaniasis Necrotizing No No No No No No Yes Yes Yes Yes Yes No Yes Yes Variable Yes No Yes Yes Yes a Includes histoplasmosis, blastomycosis, paracoccidioidomycosis, coccidioidomycosis, sporotrichosis, cryptococcosis, aspergillosis, mucormycosis, candidiasis, etc.
Anticancer Agents: Frontiers in Cancer Chemotherapy by Iwao Ojima, Gregory D. Vite, Karl-Heinz Altmann