Get Antiangiogenic Agents in Cancer Therapy (Cancer Drug PDF

By Beverly A. Teicher

ISBN-10: 0896036413

ISBN-13: 9780896036413

ISBN-10: 1592594530

ISBN-13: 9781592594535

Beverly Teicher and a panel of individual investigators survey the cutting-edge of antiangiogenesis examine from the lab bench to scientific trials. well timed and authoritative, the individuals summarize our present figuring out of tumor progress and its dependence on vascular improvement, in addition to the current prestige of antiangiogenic brokers in preclinical and scientific improvement. moreover, the booklet additionally examines what's recognized concerning the mechanisms in which those healing brokers intervene with tumor vasculature and grapples with the matter of creating standards through which to evaluate their medical efficacy. Antiangiogenic brokers in melanoma remedy bargains a different state-of-the-art compendium of antiangiogenic learn, taking inventory of what has been comprehensive , the place the experimental therapeutics of antiangiogenic brokers goes, and the continued evolution in their position in melanoma therapy and novel drug improvement.

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Viske, C. , and Durand, R. E. (1994) Hypoxic fractions measured in murine tumors and normal tissues using the comet assay. Int. J. Radiat. Oncol. Biol. Phys. 29, 487–491. 30. Urtasun, R. , Parliament, M. , McEwan, A. , Mercer, J. , Mannan, R. , Wiebe, L. , and Chapman, J. D. (1996) Measurement of hypoxia in human tumours by non-invasive spect imaging of iodoazomycin arabinoside. Br. J. Cancer 74(Suppl. XXVII), S209–S212. 31. McCoy, C. , McIntyre, D. J. , Robinson, S. , Aboagye, E. , and Griffiths, J.

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Cell 79, 315–328. 13. Mignatti, P. and Rifkin, D. B. (1996) Plasminogen activators and matrix metalloproteinases in angiogenesis. Enzyme Protein 49, 117–137. 14. Hu, D. , and Fan, T. P. (1993) Interleukin-8 stimulates angiogenesis in rats. Inflammation 17(2), 135–143. 15. Adams, D. H. and Lloyd, A. R. (1997) Chemokines: leucocyte recruitment and activation cytokines. Lancet 349, 490–495. 16. Polverini, P. J. (1997) Role of macrophages in angiogenesis-dependent disease. EXS Regul. Angiogenesis 79, 11–28.

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Antiangiogenic Agents in Cancer Therapy (Cancer Drug Discovery and Development) by Beverly A. Teicher

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