By Maria M. Picken MD PhD FASN, Ahmet Dogan, Guillermo A. Herrera
The moment version of this article offers an summary of the latest advancements during this quarter together with scientific presentation, etiology, pathogenesis, and differential prognosis. the reason for numerous remedies, together with transplantation, is mentioned and tissue analysis (its pitfalls and techniques for fending off them) and laboratory help are integrated. The involvement of all significant organ structures together with renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central fearful approach, tender tissue, epidermis, lymph node/spleen and bone marrow pathology is usually covered.
Amyloid and comparable issues, moment Edition could be useful to really expert and basic pathologists in addition to cytopathologists. different doctors can also reap the benefits of this concise replace at the systemic amyloidoses.
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Extra info for Amyloid and Related Disorders: Surgical Pathology and Clinical Correlations
140. Pokkuluri PR, Solomon A, Weiss DT, Stevens FJ, Schiffer M. Tertiary structure of human lambda 6 light chains. Amyloid. 1999;6:165–71. 141. Randles EG, Thompson JR, Martin DJ, RamirezAlvarado M. Structural alterations within native amyloidogenic immunoglobulin light chains. J Mol Biol. 2009;389:199–210. 142. Poshusta TL, et al. Mutations in speciﬁc structural regions of immunoglobulin light chains are associated with free light chain levels in patients with AL amyloidosis. PLoS One. 2009;4:e5169.
Nature. 2002;416:535–9. 74. Liao R, et al. Infusion of light chains from patients with cardiac amyloidosis causes diastolic dysfunction in isolated mouse hearts. Circulation. 2001;104:1594–7. 75. Brenner DA, et al. Human amyloidogenic light chains directly impair cardiomyocyte function through an increase in cellular oxidant stress. Circ Res. 2004;94:1008–10. 76. Shi J, et al. Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-canonical p38alpha MAPK pathway.
Randles EG, Thompson JR, Martin DJ, RamirezAlvarado M. Structural alterations within native amyloidogenic immunoglobulin light chains. J Mol Biol. 2009;389:199–210. 142. Poshusta TL, et al. Mutations in speciﬁc structural regions of immunoglobulin light chains are associated with free light chain levels in patients with AL amyloidosis. PLoS One. 2009;4:e5169. 143. Bellotti V, Mangione P, Merlini G. Review: immunoglobulin light chain amyloidosis–the archetype of 2 Amyloid Diseases at the Molecular Level: General Overview and Focus on AL Amyloidosis 144.
Amyloid and Related Disorders: Surgical Pathology and Clinical Correlations by Maria M. Picken MD PhD FASN, Ahmet Dogan, Guillermo A. Herrera